Interaction between hemoglobin subunits in the hemoglobin . haptoglobin complex.

Interaction between hemoglobin subunits in the hemoglobin . haptoglobin complex.

The accessibility of hemoglobin sulfhydryl groups to modification by p-mercuribenzoate @"B) was tested in order to investigate the effect of the hemoglobinhaptoglobin association on the contact between a and /3 chain subunits. Previous evidence indicates that a molecule of tetrameric hemoglobin binds to haptoglobin as two separate a& dimers. Modification of the hemoglobin a and B chain sullhydr...

Kinetics and Mechanism of Complex Formation between Hemoglobin and Haptoglobin*

The interaction between human hemoglobin and haptoglobin has been followed by measuring the quenching of haptoglobin fluorescence associated with complex formation. The effects of varying the concentration of the reactants suggest that hemoglobin tetramers do not react with haptoglobin, but that hemoglobin subunits are involved. Separated a! chains of hemoglobin react with haptoglobin; although...

Clearance kinetics of haptoglobin-hemoglobin complex in the human.

The peroxidase-like activity of the hemoglobin-haptoglobin complex.

Heterotropic Effect of β-lactam Antibiotics on Antioxidant Property of Haptoglobin) 2-2(-Hemoglobin Complex

Haptoglobin (Hp) is a mammalian serum glycoprotein showing a genetic polymorphism with three types, 1-1, 2-2 and 1-2. Hp appears to conserve the recycling of heme-iron by forming an essentially irreversible but non-covalent complex with hemoglobin which is released into the plasma by erythrocyte lysis. As an important consequence, Haptoglobin-Hemoglobin complex (Hp-Hb) shows considerable antiox...